Solid-phase synthesis of optically active substituted 2 aminofuranones using an activated carbonate linker.
نویسندگان
چکیده
An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. alpha-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product.
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عنوان ژورنال:
- Molecules
دوره 14 10 شماره
صفحات -
تاریخ انتشار 2009